Five new cadinane-type sesquiterpenes from the heartwood of Chamaecyparis obtusa var. formosana.

نویسندگان

  • Yueh-Hsiung Kuo
  • Chia-Hsien Chen
  • Shih-Chang Chien
  • Yun-Lian Lin
چکیده

Muurola-4,10(14)-dien-3-one (1), 10-O-acetyl-15-oxo-alpha-cadinol (2), 15-hydroxy-alpha-cadinol (3), 4alpha-hydroxy-5beta-ethoxy-epi-cubenol (4), and 4alpha-hydroxy-5beta-acetoxy-epi-cubenol (5), five new bicyclic sesquiterpenes, have been isolated from the heartwood of Chamaecyparis obtusa var. formosana along with the known compounds epi-cubenol, T-cadinol, T-muurolol, delta-cadinol, and alpha-cadinol. The structures of the new constituents were elucidated through chemical and spectral studies.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

New lignans from the heartwood of Chamaecyparis obtusa var. formosana.

Four new lignans, 3',4'-O,O-demethylenehinokinin (1), chamalignolide (2), 8'beta-hydroxyhinokinin (3) and 7beta,8beta-epoxyzuonin A (4), as well as (-)-hinokinin (5), and (-)-zuonin A (6), were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structures of these lignans were unambiguously determined by spectroscopic methods. And the absolute configuration of 1 was elucida...

متن کامل

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.0]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against ...

متن کامل

Anti-termitic activities of essential oils from coniferous trees against Coptotermes formosanus.

In this study, the anti-termitic activities of 11 essential oils from three species of coniferous tree against Coptotermes formosanus Shiraki were investigated using direct contact application. Results demonstrated that at the dosage of 10 mg/g, the heartwood and sapwood essential oils of Calocedrus macrolepis var. formosana and Cryptomeria japonica and the leaf essential oil of Chamaecyparis o...

متن کامل

A new phenolic glycoside from Chamaecyparis obtusa var. breviramea f. crippsii.

A new phenolic glycoside, 3-methoxyphenol 1-O-α-L-rhamnopyranosyl-(1→6)- O-β-D-glucopyranoside (1), was isolated from the 90% acetone extract of the branches and leaves of Chamaecyparis obtusa var. breviramea f. crippsii along with another 10 known phenolics 2-11. Their structures were determined mainly by means of MS, 1D- and 2D-NMR data. Cytotoxicities of compounds 3 and 5-11 were tested on B...

متن کامل

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells.

Microtubule is a popular target for anticancer drugs. Chamaecypanone C, is a natural occurring novel skeleton compound isolated from the heartwood of Chamaecyparis obtusa var. formosana. The present study demonstrates that chamaecypanone C induced mitotic arrest through binding to the colchicine-binding site of tubulin, thus preventing tubulin polymerization. In addition, cytotoxic activity of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of natural products

دوره 65 1  شماره 

صفحات  -

تاریخ انتشار 2002